Based on the increments of glutathione disulfide (GSSH), SOD, Ac-FOXO1, GSH, SIRT1, Nrf2, HO-1, and NQO-1, genistein inhibited oxidative stress through the SIRT1/Nrf2 pathway, providing a basis for high-salt diet-induced hypertension treatment [60]. This evidence concerns the gene NFE2L2 and hypertensive disorder.