The fact that this association remained significant only in children with obesity suggests a potentially protective role of sTAC against lipid damage in individuals with obesity, who, according to our results, might have compromised antioxidant protection in the absence of the protective genotypes conferred by the A alleles of SOD2 rs4880 (recessive model) and GPX1 rs1050450 (dominant model). Here, GPX1 is linked to obesity due to melanocortin 4 receptor deficiency.