Baicalin alleviates NOD-like receptor pyrin 3 inflammasome (NLRP3) and NF-κB signaling in piglet mononuclear phagocytes during GPS infection [26] and inhibits the release of high mobility group box 1 (HMGB1) protein in peripheral blood monocytes induced by GPS infection [27]. Here, HMGB1 is linked to infection.