AGT and airway hyperresponsiveness: Figure 1 provides a simplified representation of the inflammatory balance regulated by RAS. The RAS, primarily known for its role in blood pressure regulation, significantly influences inflammatory processes and tissue remodeling, making it central to the development and progression of asthma [76]. Notably, the detrimental effects of the AngII/AT1 pathway have been confirmed in inflammation, airway remodeling, and airway hyperresponsiveness in asthma [75].