CYBB and neuroblastoma: Evidence from neuroblastoma cells and HEK293 cells suggests synergistic activation of TRPM2 channels and NOX-2, with a positive feedback relationship between the two proteins (NOX-2 providing ROS for TRPM2 activation and TRPM2 activation providing Ca2+ for NOX-2 activation), contributing to the generation of initial Ca2+ signals and triggering downstream signalling [17,61].