Patient-derived VSMC: TRPM2 inhibition (siRNA/chemical) reduced Ang II-induced Ca2+ influx. Hypertensive LinA3 mouse model: TRPM2 inhibitors reverse hypertension-associated hypercontractility of mesenteric arteries [155]. TRPM2 activation in EC: ↑Endothelial barrier dysfunction [156]. ↑EC dysfunction [157]. This evidence concerns the gene AGT and hypertensive disorder.