METTL3 and Alzheimer disease: AP treatment improved cognitive skills of AD WT rats (Escape latency: F(1, 28) = 4.496, p < 0.05; time ratio in platform quadrant: F(1, 28) = 4.573, p < 0.05; number of crossing platform: F(1, 28) = 4.311, p < 0.05, Figure 4C–F), while knockdown of METTL3 blocked this improvement effect (Escape latency: F(1, 28) = 5.947, p < 0.05.