Herein, three cohorts of biosamples collected from subjects with ERM who had undergone phaco-vitrectomy were examined for their simultaneous expression of Reelin, in concert with Aβ1-42, FTH1 and TAU, also known as candidate hallmarks of cognitive decline (dementia and AD) [8,11,15,37,38]. The gene discussed is RELN; the disease is dementia.