RELN and retinal degeneration: To support this finding, Reelin, Aβ1-42 and FTH1 alterations have been reported to drive all pathological events observed in retinal degeneration (AMD and aceruloplasminemia), indicating that Reelin impairment and Aβ1-42 and iron toxicity take place in neurodegenerating retinas [28,40,45,46].