KAT2A and neoplasm: ACSS2, traditionally associated with acetyl-CoA synthesis, facilitates histone lactylation via lysine acetyltransferase 2A (KAT2A), also known as general control non-depressible 5 (GCN5), to promote tumor immune evasion [25], while GTPSCS drives lactyl-CoA production to support gliomagenesis [26].