Brain tumors in REMBRANDT (database) showed altered expression of KCN genes encoding H+-sensitive proteins in glioblastomas versus less invasive oligodendrogliomas of patients on anti-seizure medications, with less KCNJ16/Kir5.1; p = 5.32 × 10−8 in glioblastomas. Here, KCNJ16 is linked to brain neoplasm.