IGFBP3 and cancer: To support the relevance of cancer gene expression studies with unbiased detection of KCN DEGs, six DEGs, i.e., FGFR3, GDF15, IGFBP3, IGFBP7, KRT19, and PLAUR, each included in at least four of the E1–E70 studies, were also identified by others as encoding circulating proteins associated with a risk of cancer [223,224].