In the 3-year longitudinal multicenter study, we found that age, type 2 diabetes mellitus, CKD stages 1–3, increased LAVI (≥40 mL/m2), elevated levels of NT-proBNP (≥1440 pmol/mL), hs-CRP (≥5.40 mg/L), sST2 (≥15.5 ng/mL) and low levels of adropin (≤2.95 ng/mL) significantly predicted incident AF. The gene discussed is NPPB; the disease is atrial fibrillation.