They may include older age, a history of angina pectoris, myocardial infarction, hypertension, diabetes, thyroid dysfunction, LVH, cardiac surgery, cardiomyopathies, LA asynchrony and LA remodeling, heart rhythm disturbance, LV diastolic and systolic dysfunction, low hematocrit and hemoglobin, elevated levels of HbA1c, natriuretic peptides, galectin-3, sST2, and hs-CRP [47,48,49,50,51]. Here, LGALS3 is linked to diabetes mellitus.