In chronic granulocytic leukemia, matricellular transformation is correlated with the deletion of heterozygosity in the region where RIZ1 is, as well as with reduced RIZ1 expression and overexpression of RIZ1 in a chronic granulocytic leukemia model cell line that inhibits cell proliferation, exacerbates apoptosis, and enhances cell differentiation [20]. The gene discussed is PRDM2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.