IL6 and viral infectious disease: The hypoxic HAlone condition caused 1792 genes to be significantly upregulated (blue) or downregulated (yellow), as shown in Figure 1D. The virus infection NOC43 condition (Figure 1E) induced more (2460) changes in gene expression, including a cluster of genes indicative of the activation of immune-related pathways, including upregulation of the mRNAs of proinflammatory genes, such as IL6, CXCL8 and IL1A.