Recent research has shown that astrocytic extracellular vesicles (AEVs) derived from reactive astrocytes with anti-inflammatory properties contain CD63 and CD9 tetraspanins and miR-146a-5p, which regulate glial scars by suppressing NF-κB and TNF-α, allowing axonal growth and improving recovery from stroke [36]. This evidence concerns the gene CD9 and stroke disorder.