PTGS1 and familial hypercholesterolemia: Aspirin, a thromboxane synthesis suppressor that inhibits cyclooxygenase-1 (COX-1) irreversibly, is used to prevent cardiovascular diseases because platelet hyperactivation contributes to the known prothrombotic condition of metabolic diseases like Type 2 Diabetes Mellitus (T2DM) and familial hypercholesterolemia (HC).