73 individuals with T2DM and Diabetic Neuropathy (DN) were randomly assigned to receive a single tablet containing ten components, including, palmitoylethanolamide, SOD (70 UI), alpha lipoic acid, and vitamins, etc. The combination of the ten components in a single pill for six months at a daily dosage of two tablets considerably increases B12 levels, pain, and vibration perception threshold [241]. Here, SOD1 is linked to type 2 diabetes mellitus.