In another study, inhibiting the H2O2/Akt/NF-κB axis with curcumin may be a promising therapeutic strategy for pancreatic cancer patients and curcumin might have potential to inhibit SOD-driven H2O2-induced pancreatic cancer metastases due to its capacity for the inhibition of PI3K/Akt/NF-κB signaling pathway [119]. Here, SOD1 is linked to familial pancreatic carcinoma.