TRPM1 and age-related macular degeneration: To uncover the risk genes of AMD, integrative analyses of bulk and single-cell transcriptomics in the human eye were performed, along with the co-localization of genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL), which identified 15 putative causal genes, of which TSPAN10 and TRPM1 were enriched in RPE and associated with the risk of AMD [69].