Chen et al. [76] utilized scRNA-seq to analyze 14 UM patient samples to elucidate the relationship between intratumoral CD8+ T cells and UM metastasis, revealing that the exhaustion of CD8+ T cells in the tumor microenvironment plays a crucial role in promoting metastasis, and developed a 3-gene model including SLC25A38, EDNRB, and LURAP1 to predict metastatic risk and prognosis. The gene discussed is CD8A; the disease is neoplasm.