Hypoxia-inducible factor 1 alpha (Hif1α) is confirmed as an up-regulated EAU-associated differentially expressed gene (DEG) in Th1, Th17, and Treg cells, and enhanced Hif1α expression in CD4+ T cells was conserved and may promote their proliferation in uveitis patients [52]. The gene discussed is CD4; the disease is uveitis.