With the assistance of scRNA-seq, Pan et al. [49] identified an important immune regulator, IGFBPL1, that plays a pivotal role as a master switch, converting inflammatory microglia to their homeostatic state to prevent excessive neuroinflammation in glaucoma; hence, IGFBPL1 is a potential therapeutic target for neurodegenerative diseases featuring microglial dysregulation. This evidence concerns the gene IGFBPL1 and neurodegenerative disease.