CD8A and neoplasm: Shi et al. [74] used scRNA-seq to characterize the cellular landscape of CoM, highlighting increased CAFs in metastatic CoM, which linked to enhanced angiogenic capacity and increased VEGFR expression that drive tumor progression; additionally, they observed a relatively quiescent immunological environment with reduced total CD8+ T cells and increased naive CD8+ T cells, thus confirming the pathological and physiological characteristics of CoM at the single-cell level.