In fact, the PINK1/Parkin pathway is one of the most important mitophagy pathways, and its activation could have a role in the treatment of age-associated impairments, considering that PINK1/Parkin expression decreases in Alzheimer’s disease and osteoarthritis while also playing a role in Parkinson’s disease [94]. The gene discussed is PRKN; the disease is early-onset autosomal dominant Alzheimer disease.