PIEZO1 and dehydrated hereditary stomatocytosis: Along the same line of argumentation, when mutations or variants of Piezo1 are measured, i.e., when RBCs from patients with Hereditary Xerocytosis are investigated, we know that Piezo1 presents an altered activity [36,37] and hence, the EC50 for Yoda1 and Yoda2 will be different.