VEGFA and Hyperglycemia: The present study examined whether, in diabetic rats, the administration of DPP-IV inhibitor, an anti-hyperglycemic drug, affects the expression of mTOR, VEGF, and FLT-1 as part of their cardioprotective activity, in addition to their effect on inflammatory and apoptosis proteins, which, in turn, may contribute to the regeneration of blood vessels and reduce myocardial stress induced by hyperglycemia.