In esophageal squamous cell carcinoma, CSC can also cause the low methylation of DNMT1 and DNMT3a in the ALKBH5 CpG island, leading to the low expression of ALKBH5 and the downregulation of m6A levels (Figure 4A) [72]. This evidence concerns the gene ALKBH5 and esophageal squamous cell carcinoma.