For example, Kar et al. [125] successfully downregulated nitrosative stress and apoptosis, reduced infarct size, and improved the pathophysiology of myocardial infarction by selectively delivering an S-nitrosylated mutant of NEMO (IKKγ) (R-NEMO) via a targeting chitosan nanoparticle to the affected cardiomyocytes. The gene discussed is IKBKG; the disease is myocardial infarction.