YY1 cooperates with transcriptional coactivator PGC-1α and then enhances transcriptional activity of the ATP-binding cassette transporter 1 (ABCA1) gene, resulting in elevated ABCA1 expression levels, leading to insensitivity of colorectal cancer cells to isoliquiritigenin and tumor metastasis [37]. The gene discussed is YY1; the disease is neoplasm.