Additionally, YY1 upregulates the expression of lnc-FANCI-2 through interaction with a conserved region 3 (CR3) of E7 (human papillomaviruses oncoprotein) core motif and transactivates the promoter of lnc-FANCI-2, which is expressed from a genomic locus adjacent to the FANCI gene encoding an important DNA repair factor in in vivo and in vitro tumor cells [98]. This evidence concerns the gene YY1 and neoplasm.