In monocytes/macrophages, DDIT3 may enhance immunosuppression by promoting M2-type polarization; in fibroblasts, it may support tumor growth by regulating extracellular matrix remodeling and growth factor secretion; and in malignant cells, DDIT3 may drive proliferation, inhibit apoptosis, and enhance invasiveness. The gene discussed is DDIT3; the disease is neoplasm.