Zhu et al. [85] employed integrated multi-omics analyses to comprehensively investigate the spatial interactions between tumor cells and immune cells (such as CD8+ T cells) as well as stromal cells within the tumor TME of TNBC, with a particular focus on the critical role of the OTUD4/CD73 proteolytic axis in tumor immune evasion. This evidence concerns the gene OTUD4 and neoplasm.