BRCA2 and breast cancer: The findings indicated that BRCA1 and BRCA2 mutations exerted unique effects on gene expression in breast cancer cells: BRCA1-mutated cells exhibited a pronounced tendency for ECM degradation, specifically characterized by upregulation of matrix metalloproteinases such as MMP3 and MMP8, whereas BRCA2-mutated cells regulated ECM remodeling through integrin-mediated mechanotransduction mechanisms, such as collagen binding and cytoskeletal tension modulation.