TSC2 and acute myeloid leukemia: As homeostatic balance of oxidative stress is possibly modulated by the transcription factor NRF2 during induction of ferroptosis, we carried out DEG analyses of NRF2 target genes from Tsc2(−/−) compared to Tsc2(+/+) MEFs (Figure 3a) and TSC2-deficient and TSC2-restored AML cells (Figure 3b).