TSC2 and acute myeloid leukemia: Densitometry analysis revealed significant upregulation of HMOX1 protein expression by 16-fold (p = 0.0148), 9-fold (p < 0.0001), and 36-fold (p = 0.0032) in TSC2-deficient MEF, ELT3, and AML cells, respectively, compared with their wild-type counterparts after RSL3 treatment (Supplementary Figure S2).