F8 and breast carcinoma: In the study by Tafur A. et al., which included 21% of participants with breast cancer at various stages of the disease, it was found that patients with high FVIII levels had a 2.5-fold increased risk of developing VTE during follow-up [40], while in the study by Vormittag R. et al., which included 16% of breast cancer patients, high FVIII levels doubled the risk of VTE [39].