DNMT3A and acute myeloid leukemia: Co-mutation patterns impact prognosis in AML, and our knowledge is evolving now that, among NPM1mut AML cases, which is generally known to be chemo-sensitive with high CR rates, other co-mutation subgroups may indicate a worse prognosis with high relapse rates, such as DNMT3A co-mutation with NPM1mut AML [66].