TP53 and plasma cell myeloma: This group of double-hit MM patients includes (1) patients with biallelic alterations in critical genes, such as biallelic inactivation of the TP53 (del(17p) with TP53 mutation most of the time) or biallelic deletion of 1p32 (del(1p32)) [9,10], and (2) patients carrying any two or more HRCAs, with those harboring three or more such HRCAs also referred to as “triple-hit” myeloma [8,11].