For instance, the m6A writer METTL3 can suppress cytotoxic T-cell infiltration in colorectal cancer by destabilizing the CXCL1 and IL-8 transcripts [22], whereas the eraser ALKBH5 promotes PD-L1 degradation in melanoma through YTHDF2-mediated transcript destabilization [23]. Here, METTL3 is linked to colorectal cancer.