FTO and breast carcinoma: For instance, the AMPK signaling pathway was significantly enriched only in BRCA during ORA and was most prominently enriched in BRCA according to GSEA; prior evidence suggests that this pathway plays a crucial role in tumor suppression in breast cancer [48] and is related to RNA modifications, such as FTO-dependent m6A demethylation, regulating lipid metabolism in skeletal muscle [49].