Recurrent and high-grade meningiomas are characterized by hypermitotic and immune-enriched states characterized by FOXM1 activation, loss of CDKN2A/B, and NF2 disruption, leading to a context-dependent proliferative but tolerogenic microenvironment with M2-polarized macrophages and lymphocytic infiltration. Here, CDKN2A is linked to meningioma.