For instance, meningiomas harboring TRAF7 mutations are nearly always localized ventral to the foramen magnum of the skull base, a region now recognized as being derived from mesodermal meninges, consistent with the spatial-genotypic patterns linking TRAF7-driven tumorigenesis to mesodermal embryologic origin [63,64,65]. Here, TRAF7 is linked to meningioma.