Several additional Bayesian approaches for incorporating historical data while controlling for heterogeneity between datasets led the investigators to conclude that the incidence of spontaneous mesotheliomas in Bap1-mutant mice is significantly higher than that of WT mice (96.7–99.5% probability that the OR is >1 and 93.2–97.9% probability that it is >2). This evidence concerns the gene BAP1 and mesothelioma.