Moreover, Ren and colleagues found that the human microbial preventive peptides (LL-37) treatment of human colon cancer cell lines led to the nuclear translocation of apoptosis-inducing factor (AIF) and endonuclease G (EndoG), key mediators of caspase-independent apoptosis [70]. The gene discussed is AIFM1; the disease is malignant colon neoplasm.