In a recent immunophenotyping study including breast, pancreatic, and HNSCC, a combined immunotype signature including NKs, dendritic cells, and PD-L1+/CD8+ T-cells demonstrated good predictive ability for treatment response (chemotherapy and immunotherapy) and increased NK levels during treatment were proved as a surrogate marker of therapy response [64]. Here, CD274 is linked to head and neck squamous cell carcinoma.