Malignancies, including small-cell lung cancer (SCLC), thymic carcinomas, and pancreatic neuroendocrine tumors, release ACTH, which causes adrenal hyperplasia resulting in excessive cortisol production [49,50,51,52], which most commonly leads to weight gain, moon facies, truncal obesity, hypertension, and hyperglycemia [53,54]. Here, POMC is linked to small cell lung carcinoma.