Shekari and colleagues [19] showed that decreasing the interactions between IGSF11 and VISTA after silencing IGSF11 could change the cytokine profile of human T-cells towards a more pro-inflammatory state, which aids T-cells in becoming more activated and transforming the immunosuppressive tumor microenvironment into a more anti-tumoral one. The gene discussed is IGSF11; the disease is neoplasm.