It was found that a panel of methylated Interferon Regulatory Factor 4 (IRF4), IKAROS family Zinc Finger 1 (IKZF1) and Branched-chain amino acid transaminase 1 (BCAT1) genes effectively distinguished CRC patients from non-cancer patients, with a sensitivity and specificity of 73.9% and 90.1% (AUC = 0.82), respectively [86]. The gene discussed is IRF4; the disease is cancer.