The combination of Polypeptide N-Acetylgalactosaminyltransferase 9 (GALNT9) and up-frameshift regulator of nonsense transcripts homolog A (UPF3A) gene methylation status developed by Gallardo-Gomez et al. presents results suggesting its potential use as a highly specific, non-invasive test for screening and early detection of CRC. The gene discussed is UPF3A; the disease is colorectal carcinoma.