SFRP2 and colorectal carcinoma: Surprisingly positive results were presented in the same year by Liu et al., who showed that the use of a combination of three DNA methylation biomarkers detected in stool, SEPT9, SDC2 and Secreted Frizzled Related Protein 2 (SFRP2) showed sensitivity and specificity of 94.1% and 89.2% (AUC = 0.94), respectively, for the detection of CRC in a group of 1142 patients with intestinal abnormalities.