CD274 and neoplasm: In the control subgroups, an increase in Pd-l1 mRNA expression negatively correlated with tumor volume: Pd-l1 mRNA levels in the RLS40High subgroup were the lowest (11.4 ± 1.9), and the highest increase in Pd-l1 mRNA expression was detected in the RLS40Med and RLS40Low subgroups (23.7 ± 1.2 and 25.0 ± 4.3, respectively).