Thus, the B16 model did not show the common feature observed in the case of both RLS40 and LLC models with standard tumor size (tumor node≥ 1 cm3), where splenic neutrophils could exhibit moderate or high expression of the adhesion marker Icam1 (at the mRNA level), higher PD-L1 expression, and immunosuppressive markers (Il10 mRNA for LLC and Ccl17 mRNA for RLS40). Here, ICAM1 is linked to neoplasm.