For instance, insulin-like growth factor binding protein 3 (IGFBP-3), Cullin1 (Cul1), Golgi phosphoprotein 3 (GOLPH3), and aquaporin 1 (AQP1) have all been associated with glioma progression and invasiveness [49,50,51,52]. The gene discussed is IGFBP3; the disease is central nervous system cancer.