CD276 and neoplasm: Similarly, a Ki-67 index > 25% was strongly associated with high B7-H3 expression (univariate OR = 4.6; 95% CI: 2.1–10.2; p < 0.001; multivariate OR = 3.7; 95% CI: 1.5–9.0; p = 0.005), suggesting a link between B7-H3 expression and biologically aggressive tumor behavior.