Additionally, the Ki-67 proliferation index was significantly higher in the HGG group (median 30%, 95% CI: 25.0–60.0) compared to the LGG group (median 5%, 95% CI: 4.0–20.0) (p < 0.001), indicating increased tumor cell proliferation in HGG. The gene discussed is MKI67; the disease is neoplasm.