Increased frequencies of spontaneous and miniature excitatory postsynaptic currents in dentate granule cells of the Emx1-cKO mice further support the epileptic phenotype, suggesting that hyperexcitability in glutamatergic neurons plays a role in the seizures observed in CDKL5 deficiency disorder (CDD) [16,268]. Here, CDKL5 is linked to craniodiaphyseal dysplasia.