In summary, compared to RLAs, the RHA rats present alterations of pre- and postsynaptic markers as well as trophic factors in the PFC and/or hippocampus (HPC) (e.g., neuregulin1, homer1, synaptophysin, brain-derived neurotrophic factor-BDNF), which are associated with dysfunctional glutamatergic and dopaminergic neural systems, altered PFC maturation, and psychiatric disorders (e.g., [2,3,4,14,15,16], and references therein). The gene discussed is BDNF; the disease is psychiatric disorder.