MIR140 and neoplasm: Among the miRNA genes located in hotspot deletions are MIR140, MIR132, MIR212,andMIR22, which act as tumor suppressors [52–54], and the entire chromosome 19 cluster (C19MC), which consists of 46 miRNA genes involved in the regulation of the cell cycle and proliferation [55], including MIR520E, which we identified as frequently mutated in the LUN samples (Fig. 4A).