Matrix stiffness has been documented to regulate the expression of key tumor genes through various signaling pathways, including the integrin β1/Piezo1 activation/Ca2+ influx pathway, RhoA/ROCK pathway, YAP-POSTN-integrin mechanotransduction signaling, and YAP/TEAD4/ACADL axis [34–37]. The gene discussed is PIEZO1; the disease is neoplasm.