ALKBH1 and colorectal carcinoma: Notably, ALKBH1 expression exhibited a significant negative correlation with DNA 6 mA modification levels in primary CRC tumors (human cohort: n = 69, R=-0.4485, P < 0.001; mouse cohort: n = 27, R=-0.3703, P < 0.01) (Fig. 4C-D).