ALKBH1 and gastric cancer: Subsequently, Li et al. reported that 1 H-pyrazole-4-carboxylic acid derivative 29 is a highly effective ALKBH1 inhibitor, and they developed a prodrug 29 (named 29E) [41].Treatment with 29E significantly inhibited gastric cancer cell viability by increasing 6 mA abundance, and the hydrolysate of 29 exhibited high exposure in mice after administration [41].