The performance of the FTD diagnostic panel to discriminate FTD from AD was considerably lower (FTD diagnostic panel AUC: 0.77, 95% CI: 0.67–0.86; for comparison: CSF NfL AUC: 0.80, 95% CI: 0.72–0.88, Fig. 2B). Here, NEFL is linked to frontotemporal dementia.