The top 5 differentially regulated proteins related to FTD (median q: 2.5− 07) are involved in the regulation of the Wnt signaling pathway (WIF1), tissue remodeling (MMP7), neuronal biosynthesis (APP), cell proliferation (NPDC1), and innate immunity (IL1RL2). Here, IL1RL2 is linked to frontotemporal dementia.