Experiments from N6AMT1 knockdown by siRNA in vitro, and overexpression of N6AMT1, confirmed the hypothesis that N6AMT1 regulates the NRF2/HMOX1 pathway in GIST cells, pointing to a vital role of N6AMT1 in β‐elemene‐mediated ferroptosis. The gene discussed is HMOX1; the disease is gastrointestinal stromal tumor.