AKT1 and breast cancer: In BC preclinical models, the loss of integrin beta1, in particular, has been well demonstrated to induce and sustain dormancy by disrupting the integrin β1-Focal Adhesion Kinase signalling axis, which is crucial for pro-survival pathways, including phosphatidylinositol 3-kinase (PI3K)/Akt signalling [77, 78].