CD8A and cancer: Interactions between lipid metabolism in cancer cells and CD8+ T cells function as key drivers of the impaired tumor clearance ability of this immune subset.5,6 Tumor cell ZDHHC palmitoyltransferase 3 (ZDHHC3) stabilizes SREBP cleavage-activating protein (SCAP) via S-acylation at Cys264, thereby inhibiting its ubiquitination.