This finding aligns with clinical observations correlating increased dietary DHA intake with reduced colorectal cancer risk in patients with high CD8+ T-cell infiltration.53 Remarkably, DHA supplementation restored antitumor efficacy in CD8+ T lymphocytes preexposed to CM from TACC3-overexpressing HCC cells, establishing TACC3-driven metabolic rewiring as a mechanism of immune evasion through manipulation of the n-3 PUFA pathway. Here, TACC3 is linked to hepatocellular carcinoma.