CD8A and neoplasm: Intriguingly, while n-6 PUFA derivatives such as LA enhance cytotoxic T lymphocyte function through mitochondrial optimization, the immunoregulatory function of tumor-derived n-3 PUFA metabolites remains poorly understood.8 Our key findings demonstrate that DHA, the terminal metabolite of the n-3 PUFA pathway, potentiates CD8+ T-cell-mediated tumor cytotoxicity.