Rosmarinic acid and resveratrol attenuate cardiac dysfunction through SIRT1-mediated PGC-1α deacetylation, while Astragalus-derived astragaloside IV enhances mitogenesis via SIRT1/PGC1α/NRF1 and stabilizes mitochondrial dynamics in nephropathy [229–233]. Here, SIRT1 is linked to kidney disorder.