SIRT1 and peripheral neuropathy: NaB further rescues neuronal mitophagy by blocking RELA-HDAC8 repression of Parkin, while the SIRT1 activator piceatannol (PCN) enhances both mitogenesis and mitophagy via SIRT1/PGC1α and SIRT1/PINK1/Parkin axes, alleviating peripheral neuropathy [203, 204].