Neurons from Hexb-/- mice also exhibited elevated expression of several proteins associated with neurodegenerative diseases and/or lysosomal dysfunction in comparison to WT controls, such as amyloid precursor protein (APP), several species of phosphorylated tau, presenilin 1 (PSEN1), and ubiquitin102,106–110. This evidence concerns the gene HEXB and neurodegenerative disease.