In a large case–control study by Forkosh et al,10 the frequency of the APC I1307K variant in non-AJ white patients with CRC was 64/26563 (0.24%): these were ascertained from clinical genetic testing data from Invitae, a US commercial laboratory, and described as being of self-reported French Canadian or white ethnicity (although the breakdown therein was not delineated). The gene discussed is APC; the disease is colorectal carcinoma.