APC and colorectal cancer: The APC (NM_000038.6) c.3920T>A p.Ile1307Lys (I1307K) missense variant has been associated with a moderate/low increased risk of colorectal cancer (CRC) in individuals of Ashkenazi Jewish (AJ) descent, in whom the allele frequency is the highest (minor allele frequency (MAF): 3.7%).