CES1 and fatty liver disease: Interestingly, hepatic Ces2c deficiency promotes liver steatosis (7) whereas loss of hepatic Ces1d (formerly called Ces3/triglyceride hydrolase [TGH]) increases hepatic TG accumulation in chow-fed mice but has no effect on hepatic steatosis in Western diet–fed mice due to its role in fatty acid oxidation (FAO) and VLDL secretion (8).