Interestingly, hepatic Ces2c deficiency promotes liver steatosis (7) whereas loss of hepatic Ces1d (formerly called Ces3/triglyceride hydrolase [TGH]) increases hepatic TG accumulation in chow-fed mice but has no effect on hepatic steatosis in Western diet–fed mice due to its role in fatty acid oxidation (FAO) and VLDL secretion (8). Here, PNPLA2 is linked to fatty liver disease.