They found that in patients with chronic alcoholism, intestinal bacteria and LPS can stimulate the formation of neutrophil extracellular traps (related to tumor immunity in hepatocellular carcinoma [HCC]) through the TLR4 pathway to promote alcoholic liver fibrosis and play a significant role in the development of alcoholic liver cirrhosis and subsequent HCC. The gene discussed is TLR4; the disease is hepatocellular carcinoma.